Guidance on allergenicity assessment of genetically modified plants

Published:
Adopted:
EFSA Journal logo
Wiley Online Library

Meta data

DOI
https://doi.org/10.2903/j.efsa.2017.4862
Keywords
guidance, allergenicity assessment, newly expressed proteins, endogenous allergenicity, GMO
On request from
EFSA
Question Number
EFSA-Q-2014-00547
Panels
Genetically Modified Organisms
Panel members at the time of adoption
Andrew Nicholas Birch, Josep Casacuberta, Adinda De Schrijver, Mikolaj Antoni Gralak, Philippe Guerche, Huw Jones, Barbara Manachini, Antoine Messean, Hanspeter Naegeli, Elsa Ebbesen Nielsen, Fabien Nogue, Christophe Robaglia, Nils Rostoks, Jeremy Sweet, Christoph Tebbe, Francesco Visioli and Jean-Michel Wal.

Abstract

This document provides supplementary guidance on specific topics for the allergenicity risk assessment of genetically modified plants. In particular, it supplements general recommendations outlined in previous EFSA GMO Panel guidelines and Implementing Regulation (EU) No 503/2013. The topics addressed are non-IgE-mediated adverse immune reactions to foods, in vitro protein digestibility tests and endogenous allergenicity. New scientific and regulatory developments regarding these three topics are described in this document. Considerations on the practical implementation of those developments in the risk assessment of genetically modified plants are discussed and recommended, where appropriate.

© European Food Safety Authority, 2017
GMO