EFSA adopts final scientific opinion on animal cloning

Prof. Vittorio Silano, chair of EFSA’s Scientific Committee^[2], said:

“It is clear there are significant animal health and welfare issues for surrogate mothers and clones that can be more frequent and severe than for conventionally bred animals. For cattle and pigs, food safety concerns are considered unlikely. No clear evidence has emerged to suggest any differences between food products from clones or their offspring, in terms of food safety, compared to products from conventionally bred animals. But we must acknowledge that the evidence base, while growing and showing consistent findings, is still small. That has been one of the challenges throughout this work.”

Some of the key conclusions of the opinion include:

• Uncertainties in the risk assessment  A specialised field of applied science that involves reviewing scientific data and studies in order to evaluate risks associated with certain hazards. It involves four steps: hazard identification, hazard characterisation, exposure assessment and risk characterisation. arise due to the limited number of studies available, the small sample sizes investigated and, in general, the absence of a uniform approach that would allow all the issues relevant to this opinion to be more satisfactorily addressed. Only pigs and cattle are addressed in this opinion: the two species A subdivision of the genus, a species is a group of closely related and similar-looking organisms; for example, in the case of Homo sapiens (humans), the second part of the name (sapiens) represents the species. of animals where adequate data were available.
• The health and welfare of a significant proportion of clones, mainly within the juvenile period for cattle and perinatal period for pigs, have been found to be adversely affected, often severely and with a fatal outcome.
• Somatic Cell Nucleus Transfer (the most common technique used to clone animals) has resulted in the production of healthy cattle and pig clones, and healthy offspring, that are similar to their conventional counterparts based on parameters such as physiological characteristics, demeanour and clinical status.
• There is no indication that differences exist in terms of food safety for meat and milk of clones and their progeny compared with those from conventionally bred animals. However, such a conclusion is based on the assumption that meat and milk are derived from healthy animals which are subject to relevant food safety regulations and controls.
• No environmental impact is foreseen but there are only limited data available.

Prof. Silano added:

“EFSA cannot always offer simple answers or reassurances. Complex and evolving science and technology, where data can be limited, do not offer such neat solutions. Our advice is guided by the science and will help inform consideration of any future EU measures in relation to animal clones and products obtained from these animals and their offspring.”

Recommendations in the opinion include:

• The health and welfare of clones should be monitored during their production life and natural life span.
• As food animals other than cattle and pig have also been produced via SCNT, risk assessments should be performed on these species when relevant data become available.
• Investigate further the causes of pathologies and mortality observed in clones during the gestational and postnatal periods and those observed at a lower frequency in adulthood.
• Further investigate the immunocompetence and the susceptibility of clones and their offspring to diseases and transmissible Capable of being passed between individuals in the same species, as well as between different species (e.g. from animals to humans). agents when reared and kept under conventional husbandry conditions.
• Perform studies on animal welfare, including behavioural studies, in healthy clones under normal husbandry conditions.

See also:

• Opinion on Food Safety, Animal Health and Welfare and Environmental Impact of Animals derived from Cloning by Somatic Cell Nucleus Transfer (SCNT) and their Offspring and Products Obtained from those Animals
• EGE website and opinion on Ethical aspects of animal cloning for food supply
• Key topic section on animal cloning including Frequently Asked Questions (FAQs)