Inorganic arsenic in food – health concerns confirmed

The European Commission asked EFSA to update its assessment of inorganic arsenic to consider new studies on its toxic effects. EFSA consulted external stakeholders on its draft opinion and considered the numerous comments that were received before it was finalised.

What foods contain inorganic arsenic

Arsenic is a widely-occurring contaminant which is present both naturally and as a result of human activity. Arsenic appears in various forms, depending on its chemical structure. EFSA’s present opinion focuses on inorganic arsenic.

Food is the main source of exposure to inorganic arsenic for the general population Grupp av människor, djur eller växter av samma art. in Europe. The main contributors to dietary exposure are rice, rice-based products, and grains and grain-based products. Drinking water also contributes to exposure, although levels are usually low in Europe.

Health risks

Long-term intake of inorganic arsenic has been associated with a range of adverse effects on human health, including some forms of cancer. For its assessment, EFSA considered the increased incidence of skin cancers associated with inorganic arsenic exposure as the most relevant harmful effect. The experts concluded that ensuring protection against skin cancer will also be protective against other potentially harmful effects.

When assessing genotoxic and carcinogenic substances that are unintentionally present in the food chain, EFSA calculates a margin of exposure ( MOE Exponeringsmarginal (margin of exposure) är ett verktyg som används vid riskbedömning för att undersöka de säkerhetsproblem som uppstår till följd av förekomsten av ett potentiellt toxiskt ämne i livsmedel eller djurfoder.) for consumers. The MOE is a ratio of two factors: the dose at which a small but measurable adverse effect is observed, and the level of exposure to a substance for a given population. A low MOE represents a greater risk than a higher MOE.

Based on the available data from human studies, an MOE of 1 or less would correspond to an exposure level to inorganic arsenic that might be associated with an increased risk of skin cancer.

In adults, the MOEs are low – ranging between 2 and 0.4 for average consumers, and between 0.9 and 0.2 for high consumers. Experts concluded that this raises a health concern.

Next steps

EFSA is also assessing the potential risks linked with exposure to organic arsenic in food. Once this risk assessment is completed, the possible risks of combined exposure to organic and inorganic arsenic in food will be assessed.